https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51358 Wed 28 Feb 2024 16:08:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17112 Wed 11 Apr 2018 13:30:06 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46031 NTR), are increasingly implicated in cancer progression, but their clinicopathological significance in oesophageal cancer is unclear. In this study, the expression of NGF, NTRK1 and NGFR were analysed by immunohistochemistry in a cohort of 303 oesophageal cancers versus 137 normal adjacent oesophageal tissues. Immunostaining was digitally quantified and compared to clinicopathological parameters. NGF and NGFR staining were found in epithelial cells and at similar levels between oesophageal cancers and normal oesophageal tissue. NGFR staining was slightly increased with grade (p=0.0389). Interestingly, NTRK1 staining was markedly higher in oesophageal squamous cell carcinoma (OR 2.31, 95%CI 1.13–4.38, p<0.0001) and significantly lower in adenocarcinoma (OR 0.50, 95%CI 0.44–0.63, p<0.0001) compared to normal oesophageal tissue. In addition, NTRK1 staining was decreased in grade 2 and grade 3 (OR 0.51, 95%CI 0.21–1.40, p<0.0001) compared to grade 1, suggesting a preferential involvement of this receptor in the more differentiated forms of oesophageal carcinomas. Together, these data point to NTRK1 as a biomarker and a candidate therapeutic target in oesophageal squamous cell carcinoma.]]> Wed 09 Nov 2022 15:59:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1829 Sat 24 Mar 2018 08:31:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1737 Sat 24 Mar 2018 08:27:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12861 Sat 24 Mar 2018 08:14:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24595 14 g of tobacco per day were observed to have over 4-times the odds of developing OC (males OR = 4.36, 95% CI 2.24-8.48; females OR = 4.56, 95% CI 1.46-14.30), with pipe smoking showing the strongest effect. Similar trends were observed for the alcohol-related variables. The quantity of ethanol consumed was the most important factor in OC development rather than any individual type of alcoholic beverage, especially in smokers. Males and females consuming >53 g of ethanol per day had approximately 5-times greater odds in comparison to non-drinkers (males OR = 4.72, 95% CI 2.64-8.41; females OR = 5.24, 95% CI 3.34-8.23) and 8.5 greater odds in those who smoked >14 g tobacco daily. The attributable fractions for smoking and alcohol consumption were 58% and 48% respectively, 64% for both factors combined. Conclusion: Tobacco and alcohol use are major risk factors for OC development in this region. Impact: This study provides evidence for further reinforcement of cessation of smoking and alcohol consumption to curb OC development.]]> Fri 01 Apr 2022 09:30:03 AEDT ]]>